The Effect of Depo Medroxyprogesterone Acetate with LDL and HDL Levels
D. Fitri*, R. Siswishanto*
* Department of Obstetrics & Gynecology, Sardjito Hospital, Yogyakarta
ABSTRACT
Background: DMPA is the most common contraceptive used in Indonesia. It has been shown, however, that prolonged use of progestogen may alter lipid and hemostatic profile leading to thrombo-embolic disease. DMPA has been claimed to increase LDL and decrease HDL blood levels.
Objective: To find out the effect of duration of use of DMPA with the level of low density lipoprotein (LDL) and high density lipoprotein (HDL).
Material and method: A cross sectional design was used. Clients were taken from two affiliated health centers of Sardjito hospital. Women who had been using injectables contraceptives DMPA for 2 up to less than 3 years (group 1) and 3 up to 4 years (group 2) were included into the study. There were 60 subjects consisting of 30 for each group. Blood was taken for LDL and HDL examination by means of homogeneous enzymatic colorimètric assay.
Results: The mean LDL levels were 99,58 ± 28,13 and 110,37 ± 28,68 mg/dL for the group one and two respectively, which was not statistically different. The mean HDL levels were 59,96 ± 9.03 and 62,38 ± 8.66 mg/dL for the group one and two respectively, which was not statistically different.
Conclusion: There was no significant difference of LDL and HDL levels between group 1 (for 2 up to less than 3 years) and group 2 (3 up to 4 years).
Keywords: depo medroxyprogesterone acetate, duration of use, LDL, HDL.