Comparison of The Effect Intravenous and Intramyometrial Methylergometrine in Caesarean Section
A.Rohmah*, R. Siswosudarmo*, M.Hakimi*
*Department of Obstetrics & Gynecology, Sardjito Hospital, Yogyakarta*
ABSTRACT
Background: Methylergometrine still widely used as a second line drug in the treatment of postpartum hemorrhage after Oxytocin. There is a difference route of administration of Methylergometrine in Caesarean section, intravenous and intramyometrial administration.
Objective: Comparing effects of Metil-ergometrin intravenous and intramyo-metrial in the length of detachment of the placenta and the amount of bleeding in the third and fourth stage.
Design of study: Randomized Controlled Trial (RCT).
Material and method: The subjects was 96 pregnant women with indication caesarean section who qualified inclusion and exclusion criteria, from April 2012 to September 2012. Statistical tests used independent t-test and chi-square.
Results: There were no significant difference between the amount of the bleeding of the third stage and fourth stage in intravenous and intramyometrial route, there were 839.71±186.44 ml vs 880.40±181.80 ml, (95% CI: -115.32-33.94, p= 0.99), also between the mean of decrease haemoglobin concentration,0.96±0.49 g/dl vs 0.95±0.35 g/dl (95% CI: -0.17-0.18), hematocrite level 2.77±1.37% vs 2.79±1.05% (95%CI: -0.62-0.37). In the length of detachment of the placenta, there is no significantly different, intravenous route were 2.15±0.75 minutes and intramyometrial 2.32±0.90 minutes, 95%CI: -0.5-0.17
Conclusion: There were no significantly different effect between intravenous route and intramyometrial route of methyler-gometrine in the Caesarean section
Keywords: methylergometrine, intravenous, intramyometrial