THE RELATIONSHIP BETWEEN SERUM ESTRADIOL LEVEL, BODY MASS INDEX (BMI) AGE AND MENOPAUSAL STATE TO BONE MINERAL DENSITY
Nurdianasari Dewi, M. Sulchan Sofoewan, Shofwal Widad, H.R. Siswosudarmo
Departement of Obstetrics & Gynecology, Sardjito Hospital, Yogyakarta
ABSTRACT
Background: Osteoporosis has been responsible for 2.3 million fractures yearly in the world, and among Asian women, the Indonesian have the greatest risk for suffering from osteoporosis. Low body mass index (BMI), low estradiol level and higher age are predisposing factors for low bone mineral density (BMD).
Objective: The study was undertaken to find out the relationship between menopausal status, age, estradiol level, and BMI to BMD.
Studydesign: Cross-sectional study. Material and method: The study was carried out at Sardjito Hospital from June to August 2011. Women during the peri-menopausal and postmenopausal period (age 45 to 90 years) were included into the study. Those with malignancy, hyperthyroidism, kidney diseases and those who had been done oophorectomy or under steroid hormonal therapy were excluded. BMD examination was done on Lumbar I to IV and pelvic bones using dual X-rays absorptiometry (DXA) at the Department of Radiology. Estradiol was examined using ECLIA methods. Low BMD was determined if the T-score was less than minus one (-1). Chi square test, correlation and multivariate linear regressions analysis were used for
statistical analysis while SPSS was used for data processing Results: Among 85 women being eligible to the study, 72 (84,7%) were had been undergoing menopause and 60 (70.6%) had low BMD. The risk of getting low BMD was
highest among menopausal compared to non-menopausal women (RR 3.43; 95% CI 1.26-9.32). Age showed strong negative correlation to BMD (r= -0.61; P < 0.001), while BMI and estradiol level showed positive correlation (r=0.49 and 0.39 respectively, and P=0,001). The regression line was BMD (Y) = 0.294 – 0,77 (Age) + 0.005 (Estradiol) + 0.100 (BMI).
Conclusion: The risk of getting low BMD was higher among menopausal women. There was negative correlation between age and BMD, but there were positive correlations between estradiol and BMI to BMD.
Keywords: low bone mineral density, DXA, T-score