Background: Administration of GnRH agonist on endometriosis can increased apoptosis and inhibit proliferation of endometrial cells ectopic. How the effectiveness of GnRH agonist for 3-6months prior to FIV in endometriosis needs to be studied further. Objective: To determine the effectiveness of GnRH agonists for 3-6 months before FIV output number of mature oocytes, total dose and duration of gonadotropin stimulation with a long protocol stimulation. read more

Background: Curettage is a minor operative action that mostly done in the field of Obstetrics and Gynecology. Pain caused by the actions of curettage is an individual reflection to various stimuli, received and interpreted differently influenced by emotional, motivational, cognitive, social and cultural rights. Several anesthetic techniques combined with the provision of other Medical studied for pain. Diazepam has increased GABA effect, sedatives and hypnotics, in this study combined with paracervical block.
Aim of study: Compare the intensity of pain and side effects the addition of diazepam 10 mg to paracervical block anesthesia with paracervical block only in curettage.
Design and method: Randomised control trial research. Conducted research in Dr. Sardjito hospital and Panembahan Senopati Bantul District Hospital, which lasted for six months from August 2011. Subjects who met the inclusion criteria were divided into two groups (paracervical block and diazepam 10 mg;paracervical block). Anxiety was measured with the State Trait Anxiety Inventory (STAI). Pain was measured by the Wong-Baker FACES Pain Rating Scale. Factors suspected to affect the test were analyzed by t-tests and Chi-square.
Result: There were 60 patients in this study. Provision of Diazepam 10 mg in combination with paracervical block has result in obtained lower pain scores.

Background: Preeclampsia is one of the main causes behind maternal and perinatal mortarity and morbidity. The pathogenesis remains unclear but recently many that the failure of spiral arteries remodeling will eventually lead to placental hypoxia. On preeclampsia complicated-pregnancy, the trophoblast apoptosis is considered being excesive.
Eventhought this hypothesis is till understudy, it is believed that trophoblast apoptosis regulation play a role in preeclampsia complicatedpregnancy pathophysiology. Molecular apoptosis mechanism in human is very complex and involves many signaling molecules, among
them is Bcl-2. Bcl-2 group consist of proapptosis (Bax)) and apoptosis inhibitor (Bcl- 2 and Bcl-XL).
Objective: To compare the expression of Bcl-XL protein on prcgnancy trophoblast between severe preeclampsia complicated-pregnancy and
normotension pregnancy.
Method: This cross sectional study involves population of severe preeclampsia and normotension patient that being treated at RSUP
Sardjito from October 2011 until March 2012. Placenta samples were obtained from 43 severe preeclampsia complicated-pregnancy and 38
placentas from normotension pregnancy. Bcl-XL protein expression was observed using immunohistochemistry technique. statistical
analysis was done using independent t-test (p<0.05).
Result: There was significant difference Bcl-XL protein expression on trophoblast cells in severe preeclampsia, complicated-pregnancy group
1.29±0.12 compared to normotension pregnancy group 1.71±0.14 with p=0.00. From the logistic regression analysis reveals that the presence of severe preeclamsia has a consistent statistically
significant role to the Bcl-XL protein expression with p= 0.000.
Conclusion: Bcl-XL protein expression is lower in severe preeclampsia complicated- pregnancy compared to normotension pregnancy.
Keyword : trophoblast, severe preeclampsia,Bcl-XL protein, apoptosis.

Abstract
Objective: To understand the correlation between serum estradiol levels with bone density status and using estradiol serum as a predictor of osteoporosis in
perimenopausal and postmenopausalwomen.
Method: An observational study with cross sectional design of 54 perimenopausal and postmenopausal women aged over 45 years conducted in June- August 2010 in RSUP dr. Sardjito Yogyakarta. Pearson correlation statistical test was used to determine the correlation between serum estradiol levels with bone density. Categorical variables were compared by using Chi-square test, whereas continuous variables were analyzed by One Way Anova and Student t-test. To assess the serum estradiol levels as a predictor of osteoporosis, Receiver Operator Curve (ROC) was used.
Result: There was a significant positive correlation between serum estradiol levels with bone density status (score of Bone Mineral Density / BMD) (r =
0.456, p = 0.001). Bone density is also influenced by age, Body Mass Index (BMI), and menopausal status (p <0.05), whereas physical activity, fracture
history, smoking, consumption of coffee, milk, calcium supplements, and steroids had no effect in this study (p> 0.05). ROC test produce an Area Under
Curve (AUC) of 86.32%. Cut-off point (threshold value) of estradiol as a predictor of osteopenia / osteoporosis is 18.31 with a specificity of 94.12%
and specificity of 70%.
Conclusion: Serum estradiol levels and bone density status is positively correlated and can be used as a predictor of osteopenia/osteoporosis Keywords: osteoporosis, estradiol, bone mineral density, menopause