Comparison On The Outcome Of Ovarian Stimulation By Combination Of
Clomiphene Citrate And Gonadotropin With Clomiphene Citrate Alone On
Farida Indriani, Shofwal Widad, HM. Sulchan Sofoewan
Obstetrics And Gynecology
Medical Faculty Gadjah Mada University Yogyakarta
Background: Infertile couple with the cause of unexplained infertility and male factor can follow intrauterine insemination (IUI) programas a cheap and easy method for infertility therapy. Ovarian stimulation by ombination ofclomiphene citrate and gonadotropin and also clomiphene citrate alone was done as a superovulation mode to get higher number of mature follicle to gain higher pregnancy rate.
Objective: To compare the amount of mature follicles and endometrial thickness as an outcome of ovarian stimulation between combination drug of clomiphene citrate and gonadotrophin with clomiphene citrate alone.
Methods: Observational retrospective cohort. Subject is one cycle ntrauterine insemination stimulated either by combination CC gonadotrophin or CC alone, eligible in inclusion criteria and exclusion criteria. Statistic test used was independent t-test, chi-square and logistic
Location of study: Infertility Clinic of Permata Hati, Sardjito Tertiary Hospital, Yogyakarta. Result:A total of 142 cycle from 98 couples followed IUI and stimulated by combination CC gonadotrophin (n=72) or CC alone (n=70). Multiple mature follicle number was more frequent in combination group and statistically significant 77% vs 54%, RR 1,433 (IK95%
1,118-1,836), p=0,005, while endometrial thickness > 7mm was more frequent in combination group but not statistically different with percentage 81,9% vs 74,3%, RR 1,103 (CI95% 0,926-1,315), p=0,367.
Conclusion: Ovarian stimulation by combination CC gonadotropin resulting of more multiple mature follicle number while good endometrial thickness was more in combination group but not statistically significant.